On the occasion of World Mental Health Day on 10 October 2023, The European Psychiatry released a Special Issue on The Value of Treatment (VOT) focusing on Early Intervention and Continuity of Care for Mental Disorders (Anorexia Nervosa, Autism and Major Depressive Disorder).

With this new Study, the European Brain Council (EBC), together with its members and academic partners (Hospital Universitario Gregorio Maranon, King’s College London, The London School of Economics and Political Science and University of Greenwich, is not only looking at the socio-economic impact and value of optimal healthcare interventions but is also emphasizing how timely care pathways are likely to need greater integration and how collaborative care between primary care and specialist care – inexistant in many countries – can be achieved in the future for the benefit of those living with a mental disorder.

Like any other mental disorders, anorexia nervosa, autism, and major depressive disorder all share similar challenges. People with mental health issues face complex biological, psychosocial, and healthcare needs with clear implications in terms of quality of life and costing. According to the case study results on autism, more than 60% of parents say they do not get the support they need for their child. The duration of untreated illness for adolescents with anorexia nervosa can be high. Many young adults with major depressive disorder are not receiving treatment at any one time and it is known that both duration of untreated illness and the number of ineffective treatments trialed are risk factors for poorer long-term outcomes.

Value of Treatment Scientific Publications & Articles

Rare Diseases Case Studies

Croatian Medical Journal

Toward earlier diagnosis and treatment of rare neurological disorders: the value of coordinated care and specialist centers

UCL Queen Square Institute of Neurology

Value of Specialist Centres for the treatment and care of patients with ataxia – Value of Treatment

VOT2 Value Proposition

Early coordinated care for patients affected by RNDs study


The COVID-19 pandemic impact on continuity of care provision on rare brain diseases and on Ataxia, Dystonia and PKU. A scoping review protocol

Orphanet Journal of Rare Diseases

Patient pathways for rare diseases in Europe: ataxia as an example

Orphanet Journal of Rare Diseases

Impact of specialist ataxia centres on health service resource utilisation and costs across Europe: cross-sectional survey

Mental Disorders Case Studies


The effects of COVID-19 on European healthcare provision for people with major depressive disorder: a scoping review protocol

European Psychiatry

The effects of COVID-19 on European healthcare provision for working-age adults with major depressive disorder

European Psychiatry

Economic impact of reducing treatment gaps in depression

European Psychiatry

Care pathways for people with major depressive disorder: A European Brain Council Value of Treatment study

European Psychiatry

Autism with co-occurring epilepsy care pathway in Europe

European Psychiatry

Viewpoint: Assessing the value of mental health treatments in Europe

European Psychiatry

Autism care pathway in Europe

European Psychiatry

Economic analysis of early intervention for autistic children: findings from four case studies in England, Ireland, Italy, and Spain

Journal of Autism and Developmental Disorders

Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy

International Journal of Eating Disorders

Optimising care pathways for adult anorexia nervosa. What is the evidence to guide the provision of high-quality, cost-effective services?

European Psychiatry

Quantifying the economic value of earlier and enhanced management of Anorexia Nervosa for adults in England, Germany and Spain: improving the care pathway